PROBLEM TO BE SOLVED: To provide a hepatic function disorder preventing/ameliorating agent, hepatic function disorder preventing/ameliorating food and drink and a hepatic function disorder preventing/ameliorating feed, which can be prepared easily and which contain a commonly-used material as an active ingredient.SOLUTION: This invention relates to a hepatic function disorder preventing/ameliorating agent, hepatic function disorder preventing/ameliorating food and drink and a hepatic function disorder preventing/ameliorating feed, which contain ozonized oil and fat such as ozonized olive oil as an active ingredient. The hepatic function disorder preventing/ameliorating agent can control liver fat accumulation, namely, control triglyceride accumulation in liver, and discharge only triglyceride from among lipids selectively into blood, and has an effect for reducing the concentration of PAI-1 in the blood or suppressing rise thereof.COPYRIGHT: (C)2013,JPO&INPIT【課題】容易に調製でき、慣用されている物質を有効成分とする肝機能障害予防改善剤、肝機能障害予防改善用飲食品及び肝機能障害予防改善用飼料を提供する。【解決手段】オゾン化オリーブ油等のオゾン化油脂を有効成分とする肝機能障害予防改善剤、肝機能障害予防改善用飲食品及び肝機能障害予防改善用飼料とする。上記肝機能障害予防・改善剤は、肝臓脂肪蓄積を抑制、すなわち肝臓へのトリグリセリドの蓄積を抑制し、脂質のうちトリグリセリドのみを選択的に血中へ放出させることができ、また、血中のPAI-1の濃度を低減ないし上昇抑制する効果を有する。【選択図】なし