Described are devices useful to inject fluid to tissue without the use of a needle, and related methods； the devices include one or a combination of features such as ejection orifices (40), distal end control features, or combinations of these； the systems can include a fluid delivery system having an injector source and an access device； the access device can comprise a minimally invasive, tubular delivery lumen (34) such as a catheter or endoscope； the tube-like device further includes one or more apposing jets that are selectively fired to force the injection orifice of the tube-like device against the target tissue； selective firing can include a continuous firing during the injection to improve the efficiency of the treatment.
