The present invention relates to nucleic acid sequences encoding a 22.5 kD Streptococcus uberis protein and to parts of such nucleic acid sequences that encode an immunogenic fragment of such proteins, and to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof. The invention also relates to a 22.5 kD Streptococcus uberis protein and immunogenic parts thereof encoded by such sequences. Furthermore, the present invention relates to vaccines comprising such nucleic acid sequences and parts thereof, DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acid sequences or such parts thereof, proteins or immunogenic parts thereof and antibodies against such proteins or immunogenic parts thereof. Also, the invention relates to the use of said proteins in vaccines and for the manufacture of vaccines. Moreover, the invention relates to the use of said nucleic acid sequences, proteins or antibodies for diagnostic or vaccination purposes. Finally the invention relates to diagnostic kits comprising such a nucleic acid, protein or antibodies against such protein.La présente invention concerne des séquences dacides nucléiques codant pour une protéine 22.5 kD Streptococcus uberis, des parties de ces séquences dacides nucléiques codant pour un fragment immunogène de ces protéines, des fragments dADN, des molécules dADN recombinantes, des cellules hôtes et vecteurs recombinants vivants contenant lesdites séquences dacides nucléiques ou parties de ces dernières. Ladite invention concerne également une protéine 22.5 kD Streptococcus uberis et des parties immunogènes de cette dernière codées par lesdites séquences. La présente invention concerne en outre des vaccins contenant lesdites séquences dacides nucléiques et parties de ces dernières, des fragments dADN, des molécules dADN recombinantes, des cellules hôtes et vecteurs recombinants vivant
