The present invention relates to a codon-optimized nucleotide sequence encoding MG53, its recombinants and use thereof the present invention can be applied within the fields of genetic engineering/biomedical technology. Specifically, the present invention relates to a codon-optimized nucleotide sequence encoding MG53, its recombinant vectors harboring the said sequence and host cells. The present invention also relates a method of providing a higher MG53 yield through codon-optimization and its use in biomedical filed.
