NITTOLI, Thomas,JAIN, Nareshkumar F.,MARKOTAN, Thomas Patrick
申请号：
HK16108121.7
公开号：
HK1220115A
申请日:
2016.07.12
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
The disclosure relates to compositions comprising diastereomer of a macrolide exhibiting improved therapeutic profile in the context of inhibiting cell proliferation compared to the corresponding compositions comprising mixture of diastereomers. The disclosure further provides drug-ligand conjugates formed using diastereomer of the macrolide. The disclosure also provides novel method of preparation of diastereomer of the macrolide and their therapeutic uses.
