Thomas NITTOLI,Nareshkumar F. JAIN,Thomas Patrick MARKOTAN
申请号：
US14913965
公开号：
US20160354482A1
申请日:
2014.08.26
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The disclosure relates to compositions comprising diastereomer of a macrolide exhibiting improved therapeutic profile in the context of inhibiting cell proliferation compared to the corresponding compositions comprising mixture of diastereomers. The disclosure further provides drug-ligand conjugates formed using diastereomer of the macrolide. The disclosure also provides novel method of preparation of diastereomer of the macrolide and their therapeutic uses.
