The present invention provides a novel compound/pharmaceutical composition and a method for preparing the same. The compound/pharmaceutical composition includes the following formula. The compounds exhibit significant and/or selective cytotoxic activity and are potent inhibitors of DNA topoisomerse.本發明係關於一種新穎的化合物或其醫藥組成物及其製造方法,該化合物具有如下結構式。該化合物具有顯著和/或選擇性的細胞毒殺活性,且具有高度潛力可發展成拓撲酶抑制劑。