KANG, WON HO,강원호,JUNG, WON TAE,정원태,LEE, YOUNG HO,이영호,KANG, JUNG HOON,강정훈,KIM, BYUCK HO,김벽호,KANG, WON HOKR,JUNG, WON TAEKR,LEE, YOUNG HOKR,KANG, JUNG HOONKR,KIM, BYUCK HOKR
申请号：
KR1020160133819
公开号：
KR1020180041814A
申请日:
2016.10.14
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a production method of a lyophilized composition with improved stability and solubility, which includes a step of dissolving cyclophosphamide, sodium chloride and D-mannitol in a water solvent in a reaction container at 40 to 70°C. The present invention also relates to a lyophilized cyclophosphamide composition for injection produced by the production method.본 발명은 40 내지 70℃의 반응용기에서, 물 용매에 시클로포스파미드, 염화나트륨 및 D-만니톨을 용해시키는 단계를 포함하는 안정성 및 용해도가 향상된 동결건조 조성물의 제조방법 및 이에 따라 제조된 주사제용 시클로포스파미드 동결건조 조성물에 관한 것이다.
