The invention provides compositions and methods for delivery of a bioactiveagent to an individual. Delivery vehicles are provided that include abioactive agent in disc shaped particles that include one or more lipidbinding polypeptides circumscribing the perimeter of a lipid bilayer in whichthe bioactive agent is localized. Chimeric lipid binding polypeptides are alsoprovided and may be used to add additional functional properties to thedelivery particles.