MJuLLER Dzhordzh V. (US),МЮЛЛЕР Джордж В. (US),RAChELMEN Aleksander L. (US),РАЧЕЛМЕН Александер Л. (US),MJULLER DZHORDZH V.,МЮЛЛЕР Джордж В.,RACHELMEN ALEKSANDER L.,РАЧЕЛМЕН Александер Л.
申请号：
RU2011121567/04
公开号：
RU0002527952C2
申请日:
2009.10.26
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to isoindoline compounds, such as compounds of Formula or to their pharmaceutically acceptable salts or stereoisomers, wherein X represents CH2； Y represents O, cyanamido (N-C≡N) or amido (NH)； m represents an integer of 0 or 1； R1 represents hydrogen or C1-6 alkyl； R2 represents hydrogen, C1-10 alkyl, C0-6alkyl-(5-10-merous heteroaryl containing one, two or three heteroatoms independently specified in O, S or N), C0-6alkyl-(6-merous heterocyclyl which represents morpholinyl or piperazinyl), C0-6alkyl-OH, -NHCO-C1-6alkyl, -OR21 or - (CH2-Z)-(6-merous heteroaryl which represents pyridinyl), wherein each heteroaryl and heterocyclyl is optionally substituted by one or more C1-6 alkyls； R3 represents hydrogen, halogen, -NO2, C0-6alkyl-OH, C0-4 alkyl-NH2 or -OR21； R21 represents phenyl, pyridinyl, piperidinyl or -CO(CH2)R22； R22 represents -NH2 or piperazinyl； and Z represents O； provided R1 represents hydrogen, then R2 is other than hydrogen or C1-10alkyl； provided R3 represents halogen, then R2 represents C0-6alkyl-(5-6-merous heterocyclyl). The invention also refers to pharmaceutical compositions for controlling angiogenesis or inhibiting the TNFα production on the basis of the above compounds.EFFECT: there are prepared new compounds and compositions based thereon to be used in medicine for treating or preventing a disease or a disorder, such as cancer, pain skin diseases, lung disorders, parasitic diseases, immunodeficiency disorders, CNS disorders, CNS injuries, atherosclerosis or associated disorders, sleep disorders or associated disorders.26 cl, 68 exИзобретение относится к изоиндолиновым соединениям, таким как соединения Формулы (I)или к их фармацевтически приемлемым солям или стереоизомерам, где X представляет собой CH2； Y представляет собой О, цианамидо (N-C≡N) или амидо (NH)； m представляет собой целое число 0 или 1； R1 представляет собой водород или C1-6 алкил； R2 представляет собой водород, C1-10
