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ANTICORPO MODIFICADO, ANTICORPO CONJUGADO E SEU PROCESSO DE PREPARAÇÃO
专利权人:
SYNAFFIX B.V.
发明人:
FLORIS LOUIS VAN DELFT,REMON VAN GEEL,MARIA ANTONIA WIJDEVEN
申请号:
PT13786322
公开号:
PT2911699T
申请日:
2013.10.23
申请国别(地区):
PT
年份:
2018
代理人:
摘要:
The present invention relates to an antibody comprising a GlcNAc-S(A) x substituent, wherein S(A) x is a sugar derivative comprising x functional groups A wherein A is independently selected from the group consisting of an azido group, a keto group and an alkynyl group and x is 1, 2, 3 or 4, wherein said GlcNAc-S(A) x substituent is bonded to the antibody via C1 of the N-acetylglucosamine of said GlcNAc-S(A) x substituent, and wherein said N-acetylglucosamine is optionally fucosylated. The invention also relates to an antibody-conjugate, in particular to an antibody-conjugate according to the Formula ( 20 ) or ( 20b ), wherein AB is an antibody, S is a sugar or a sugar derivative, D is a molecule of interest, and wherein said N-acetylglucosamine is optionally fucosylated (b is 0 or 1). The invention further relates to a process for the preparation of a modified antibody, to a process for the preparation of an antibody-conjugate, and to said antibody-conjugate for use as a medicament. In addition, the invention relates to a kit of parts comprising an azide-modified antibody and a linker-conjugate, wherein said linker-conjugate comprises a (hetero)cycloalkynyl group and one or more molecules of interest.
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