Siegfried Stengelin;Zhongli Gao;Werngard Czechtizky;William Joseph Hurst;Lothar Schwink
发明人:
Werngard Czechtizky,Zhongli Gao,William Joseph Hurst,Lothar Schwink,Siegfried Stengelin
申请号：
US12724035
公开号：
US08618159B2
申请日:
2010.03.15
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention discloses and claims a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I).Wherein R, R1, R2, R3 and R4 are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this invention also discloses methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefor.
