CZECHTIZKY, WERNGARD,GAO, ZHONGLI,HURST, WILLIAM J.,SCHWINK, LOTHAR,STENGELIN, SIEGFRIED
申请号：
MYPI 2010001299
公开号：
MY151348A
申请日:
2008.10.14
申请国别(地区):
MY
年份:
2014
代理人:
摘要：
THE PRESENT INVENTION DISCLOSES AND CLAIMS A SERIES OF SUBTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES OF FORMULA (I). WHEREIN R, R1, R2, R3 AND R4 ARE AS DESCRIBED HEREIN. MORE SPECIFICALLY, THE COMPOUNDS OF THIS INVENTION ARE MODULATORS OF H3 RECEPTORS AND ARE, THEREFORE, USEFUL AS PHARMACEUTICAL AGENTS, ESPECIALLY IN THE TREATMENT AND/OR PREVENTION OF A VARIETY OF DISEASES MODULATED BY H3 RECEPTORS INCLUDING DISEASES ASSOCIATED WITH THE CENTRAL NERVOUS SYSTEM. ADDITIONALLY, THIS INVENTION ALSO DISCLOSES METHODS OF PREPARATION OF SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND INTERMEDIATES THEREFOR.
