Composition comprising an extract of Magnolia officinalis Rehd. et Wils. or 4-O-methylhonokiol isolated therefrom having anti-inflammatory, anti-allergy and anti-wrinkle activity
The invention Magnolia (MagnoliaofficinalisRehd.etWils. The present invention relates to a composition having an anti-inflammatory, anti-allergic, and anti-wrinkle effect, comprising an extract or a compound separated therefrom as an active ingredient, and in detail, the thick extract of the present invention and 4-O-methyl-honokiool separated therefrom ( 4-O-methylhonokiol) has the effect of inhibiting iNOS activity, inhibiting iNOS and COX2 gene expression, inhibiting PGE2, IL-6 and IL-8 production, enhancing antihistamine activity, inhibiting elastase and inhibiting MMP-1 expression. Therefore, it can be usefully used as an external skin pharmaceutical composition and cosmetic composition for anti-inflammatory, anti-allergic and wrinkle improvement.Thick Extract, 4-O-Methyl Honokiol, Anti-Inflammation, Anti-Allergic, Wrinkles본 발명은 후박(MagnoliaofficinalisRehd. etWils.) 추출물 또는 이로부터 분리된 화합물을 유효성분으로 함유하는 항염, 항알러지 및 주름 개선 효과를 갖는 조성물에 관한 것으로, 상세하게는 본 발명의 후박 추출물 및 이로부터 분리된 4-O-메틸호노키올(4-O-methylhonokiol)은 iNOS 활성 저해 효과, iNOS, COX2 유전자 발현 저해효과, PGE2, IL-6, IL-8 생성억제 효과, 항히스타민 활성 증진, 엘라스타제 저해 효과 및 MMP-1 발현 저해 효과를 나타내므로 항염, 항알러지 및 주름 개선용 피부외용 약학조성물 및 화장료 조성물로 유용하게 이용될 수 있다.
