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COMPOSITION FOR LOCAL USE CONTAINING A FILM-FORMING POLYMER FOR DELIVERY OF AN ACTIVE INGREDIENT ON SKIN
专利权人:
ЛЕО ФАРМА А/С (DK)
发明人:
ПЕТЕРССОН Карстен (DK),ФРЕДЕРИКСЕН Кит (DK),ОМКВИСТ Диана (DK),ЯНССОН Йорген (DK)
申请号:
RU2015104019
公开号:
RU2015104019A
申请日:
2013.07.05
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A film-forming pharmaceutical composition for skin use containing at least one therapeutically active ingredient dissolved in a pharmaceutically acceptable volatile solvent present in an amount of 50-99.5% w / w. composition, and the composition further comprises a film-forming polymer in an amount of 0.1-50% wt./wt., a plasticizer in an amount of 0.1-10% wt./wt., and an oil release enhancing agent in an amount of 0.1-15% w / w; the composition is capable of forming, after application to the skin and evaporation of the solvent, a continuous phase containing a film-forming polymer and a plasticizer, and a dispersed phase containing droplets of an oil enhancing release agent. 2. The composition of claim 1, wherein the film-forming polymer is selected from the group consisting of cellulose derivatives, acrylic polymers, acrylic copolymers, methacrylate polymers, methacrylate copolymers, polyurethanes, polyvinyl alcohol or a derivative thereof, such as polyvinyl acetate, silicone polymers and silicone copolymers , or their copolymers. 3. The composition according to claim 2, wherein the cellulose derivative is selected from the group consisting of ethyl cellulose, methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose. 4. A composition according to claim 2, wherein the acrylic polymer is selected from the group consisting of a copolymer of methyl methacrylate and butyl methacrylate, a copolymer of ethyl acrylate and methyl methacrylate, a copolymer of acrylate and ammonium methacrylate type A and type B, and an acrylate / octyl acrylamide copolymer. The composition according to any one of paragraphs. 1-4, characterized in that the amount of film-forming1. Пленкообразующая фармацевтическая композиция для кожного применения, содержащая по меньшей мере один терапевтически активный ингредиент, растворенный в фармацевтически приемлемом летучем растворителе, присутствующем в количестве 50-99,5% мас./мас. композиции, причем компози
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