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COMPOSITION FOR LOCAL USE CONTAINING A FILM-FORMING POLYMER FOR DELIVERY OF AN ACTIVE INGREDIENT ON SKIN
专利权人:
ЛЕО ФАРМА А/С (DK)
发明人:
ПЕТЕРССОН Карстен (DK),ФРЕДЕРИКСЕН Кит (DK),ОМКВИСТ Диана (DK),ЯНССОН Йорген (DK)
申请号:
RU2015103911
公开号:
RU2015103911A
申请日:
2013.07.05
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. Essentially anhydrous sprayable film-forming pharmaceutical composition for skin use containing at least one therapeutically active ingredient dissolved in a pharmaceutically acceptable propellant selected from the group consisting of a mixture of dimethyl ether and a second propellant selected from Salkanes, hydrofluoroalkanes, hydrochloroalkanes, fluoroalkanes and chlorofluoroalkanes, the propellant being present in an amount of 50-99.5% w / w. composition, the composition further comprises a film-forming polymer in an amount of 0.1-50% wt./wt., a plasticizer in an amount of 0.1-10% wt./wt., and an oil release enhancing agent in an amount of 0.1-15% wt. ./mass., the composition essentially does not contain a low molecular weight volatile solvent. 2. The composition of claim 1, wherein the film-forming polymer is selected from the group consisting of cellulose derivatives, acrylic polymers, acrylic copolymers, methacrylate polymers, methacrylate copolymers, polyurethanes, polyvinyl alcohol or a derivative thereof, such as polyvinyl acetate, silicone polymers and silicone copolymers , or their copolymers. 3. The composition according to claim 2, wherein the cellulose derivative is selected from the group consisting of ethyl cellulose, methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose. 4. A composition according to claim 2, wherein the acrylic polymer is selected from the group consisting of a copolymer of methyl methacrylate and butyl methacrylate, a copolymer of ethyl acrylate and methyl methacrylate, a copolymer of acrylate and ammonium methacrylate type A and type B, and an acrylate / octyl acrylamide copolymer. The composition according to any one of paragraphs. 1-4,1. По существу безводная напыляемая пленкообразующая фармацевтическая композиция для кожного применения, содержащая по меньшей мере один терапевтически активный ингредиент, растворенный в фармацевтически приемлемом пропелленте, выбранном из группы, с
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