The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel
发明人:
Liu, Jie,Weissman, Irving L.,Majeti, Ravindra
申请号：
HRP20170254
公开号：
HRP20170254T1
申请日:
2017.02.17
申请国别(地区):
HR
年份:
2017
代理人:
摘要：
Humanized or chimeric anti-CD47 monoclonal antibodies are provided. The antibodies bind to and neutralize human CD47, and find use in various therapeutic methods. Preferred are non-activating antibodies. Embodiments of the invention include isolated antibodies and derivatives and fragments thereof, pharmaceutical formulations comprising one or more of the humanized or chimeric anti-CD47 monoclonal antibodies； and cell lines that produce these monoclonal antibodies. Also provided are amino acid sequences of the antibodies.
