The present invention provides a natural composition of reducing weight gains and decreasing the accumulation of fat, comprising Bacillus subtilis BS139 (Storage ID: BCRC 910457) and Coleus forskohlii extract. Moreover, this composition can be used in the treatment of obesity, helping them healthy reduce fat accumulation, to achieve the effect of weight loss.本發明提供一種具減少體重增加和降低脂肪累積的組合物,包含有枯草桿菌(Bacillus subtilis)BS-139(寄存編號:BCRC 910457)及毛喉鞘蕊花萃取物(Forskohlii extract)。此組合物更可應用於治療肥胖者,使肥胖者真正健康的降低體內脂肪累積,而達到減輕體重的效果。