Eugen Uhlmann,Markus Weber,Romesh Subramanian,Thomas Dino Rockel,Arthur M. Krieg
申请号：
US14698312
公开号：
US09732341B2
申请日:
2015.04.28
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided.
