UHLMANN, EUGEN,SUBRAMANIAN, ROMESH,KRIEG, ARTHUR M.
申请号：
CA2884608
公开号：
CA2884608A1
申请日:
2013.09.13
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The disclosure provides multimeric oligonucleotide compounds, comprising two or more target- specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target- specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided
