UHLMANN, Eugen,SUBRAMANIAN, Romesh,KRIEG, Arthur, M.
申请号：
DK13837395
公开号：
DK2895200T3
申请日:
2013.09.13
申请国别(地区):
DK
年份:
2020
代理人:
摘要：
The disclosure provides multimeric oligonucleotide compounds, comprising two or more target-specific oligonucleotides (e.g., antisense oligonucleotides (ASOs)), each being resistant to cleavage, and linked together by a cleavable linker. In particular, two or more linked target-specific oligonucleotides, each to a different target, allows concomitant inhibition of multiple genes' expression levels, while exhibiting favorable pharmacokinetic and pharmacodynamic properties. Methods of making and uses of the described compounds are also provided
