Jong-Seob Im,Yong-Youn Hwang,Won-No Youn,Yeo-Jin Park,Hye-Min Kim,Joon-Gyo Oh,Hun-Taek Kim,Bong-Yong Lee
申请号：
US14381627
公开号：
US09622986B2
申请日:
2013.02.26
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided is a transdermal delivery system (for example, in the form of a patch) having a double-layer structure including a drug-containing matrix layer and an adhesive layer, wherein the drug-containing matrix layer is obtained by completely dissolving donepezil using a certain polymer and then formulating along with an adhesive； and a process for preparing the same. The transdermal delivery system according to the present invention does not show any crystallization of donepezil in the formulation, can release donepezil at a uniform rate for a long time, and can inhibit the release dumping phenomenon that occurs in a transdermal delivery system having a single-layer structure.
