TEICHGRBER, VOLKER,RIBBA, BENJAMIN,GRIMM, HANS PETER
申请号：
ARP170101381
公开号：
AR108552A1
申请日:
2017.05.23
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
Specifically, it refers to the management system that can identify the IL-2 receiver (preferably based on the therapeutic preparation of interleukine 2 (IL-2)). These methods help to determine the general management system of the target drug therapeutic agents in IL-2R, Although the management system in il-2r.requirements 1: methods to determine the best management system for therapeutic agents is specially formulated for the individuals who are using Diana therapeutic agents for treatment,said method comprising: a) simulating a model using data obtained from one or more individuals at one or more time points after the administration of a dose of the therapeutic agent, in which the data includes FC data referred to the amount of unbound therapeutic agent , in which the model is: in which [Ab] ₗⁱᵇʳₑ is the concentration of unbound therapeutic agent in the plasma； [IL2R] ₗⁱᵇʳₑ is the concentration of unbound immune cells that express IL-2 receptor in the blood and given by kⁱₙ / kₒᵘₜ. or optionally obtained from FC data；[complex] refers to the concentration of the complex between the therapeutic agent and the immune cells, which represent the IL-2 receptor (l2r8314 cells)；k es una tasa de eliminaci n constante del agente terap utico del plasma y presenta un valor de entre 0 02 y 0 04 horaa. The binding rate between the therapeutic agent and immune cells was 0.26-4.5mm, with a value of 8315m； 1. The binding rate between the therapeutic agent and immune cells was 0.26-4.5mm；a. The dissolution rate between the therapeutic agent and the immune cells was 0.0035 to 0.02 h 8315l, indicating that IL-2 was received, and the value was 0.035 to 0.02 h 83151；a. The constant input velocity of l2r8314 cells in the plasma was between 0.006 and 0.0144 mm h 83151；a. The natural decomposition rate of l2r8314 cells in plasma was between 0.0018 and 0.069 h 83151；a. The internalization rate of the therapeutic agent was 0.0066 to 0.023 h 8315； 1H is the stable expansion rate of i2r8314 cel
