DRESSEN, Amy,IAEA, David B.,ISMAILI, Moulay Hicham Alaoui,JACKMAN, Janet K.,LAZARUS, Robert A.,LOYET, Kelly,MAUN, Henry R.,YASPAN, Brian L.,YI, Tangsheng,ARRON, Joseph R.,HERNANDEZ-BARRY, Hilda Y.
申请号：
PE2019002075
公开号：
PE20200150A1
申请日:
2018.04.20
申请国别(地区):
PE
年份:
2020
代理人:
摘要：
FC involving a PVC to Spink, including one or more SPINK5 or spink9 domain names, wherein the SPINK5 domain name includes the sequence selected from SEQ ID No.17 and SEQ ID No.22, and the spink9 domain name includes SEQ ID No.28. This polyurethane suppresses the activity of KLK5 and is useful in the treatment or diagnosis of neheton's asthma or sindrome. Also mentioned are pharmacology composers with this polyurethaneReferida a un polipeptido de fusion a Fc de SPINK que comprende uno o mas dominios de SPINK5 o SPINK9, donde los dominios de SPINK5 comprenden una secuencia que se selecciona de SEQ ID NO:17 y SEQ ID NO:22 y los dominios de SPINK9 comprenden SEQ ID NO:28. Dichos polipeptidos inhiben la actividad de KLK5, siendo utiles en el tratamiento o diagnostico del asma o sindrome de Netherton. Tambien esta referida a composiciones farmaceuticas que comprenden dichos polipeptidos
