РАДДИ Стефен Б. (US),МАКГУРК Саймон Л. (US),ПАТЕЛ Ракеш (US),БУЛЛОК Джон (US),КЕВАЛРАМАНИ Радж (US)
申请号：
RU2011145279/15
公开号：
RU2011145279A
申请日:
2010.04.08
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A composition comprising a semi-permeable coating； drug particles having an effective average particle size of less than or about 2 microns and a surface stabilizer adsorbed on the surface of the drug particles； solubilizing agent. 2. The composition of claim 1, wherein the semi-permeable coating is selected from the group consisting of a microporous coating with controlled porosity, a water-swellable coating, and mixtures and combinations thereof. A composition according to claim 1, wherein the semipermeable coating is a microporous coating with controlled porosity, including a polymer that is insoluble in the active medium, and a pore-forming additive, soluble in the active medium. A composition according to claim 3, wherein the polymer is selected from the group consisting of polymers based on cellulose, methacrylates and phthalates and in which the pore-forming additive is selected from the group consisting of HPMC, PVP, polyhydric alcohols and sugars. The composition according to claim 3, in which the content of the pore-forming additives in the microporous coating with controlled porosity, wt.%, Selected from the group consisting of 0.5； 1.0； 1.5； 2.0； 2.5； 3.0； 3.5； four； 4,5； 5； 6； 7； 8； 9； 10； 12； 13； fifteen； 17； 19； 21； 22； 24； 26； 28； thirty； 32； 34； 36； 38； 41； 43； 45； 47； 49； and 50.6. The composition of claim 1, wherein the drug is selected from the class of drugs selected from the group consisting of abortion drugs, ACE inhibitors, α- and β-adrenergic agonists, α- and β-adrenergic blockers, adrenocortical suppressants, adrenocorticotropic hormones, drugs that prevent alcohol consumption, aldose reductase inhibitors, aldosterone antagonists, anabolics, analgesics (including n1. Композиция, содержащаяполупроницаемое покрытие；частицы лекарственного средства, имеющие эффективный средний размер частиц менее чем или приблизительно 2 мкм, и поверхностный стабилизатор, адсорбированный на поверхности частиц лекарственного средства； ипридающий растворимость
