The present invention refers to pharmaceutical microparticulate compositions of biologically active polypeptides and methods of forming and using such compositions. More particularly, microparticle compositions for sustained release of biologically active polypeptides are provided. Compositions of biologically active polypeptides with desired release profile can be prepared without using any sugar. The microparticle compositions of this invention comprise a biocompatible polymer, a biologically active polypeptide, and optionally, pharmaceutical excipients other than sugar.
