This paper openly is used for increasing or stimulation of bone growth, reduce or the prevention bone resorption, increase bone strength, improve bone structure, with dietary supplement compositions and the method for improving sclere, said composition comprises first compositions and second compositions, this first compositions comprises at least two kinds combination in following: Quercetin, Radix Rehmanniae (Rehmannia sp.), Radix Rehmanniae (Rehmannia sp.) root, Siberian ginseng, Chinese scholartree (Sophora japonica), Radix Glycyrrhizae and ipriflavone, wherein the combination of this first compositions increases the gene of bone morphogenesis protein-2, promoter or protein expression And this second compositions comprise Punica granatum L. extract and following at least a combination: Siberian ginseng, Semen Ginkgo (Ginkgo biloba), green tea, Chinese scholartree (Sophora japonica), Radix Rehmanniae (Rehmannia sp.), Semen Vitis viniferae, Radix Angelicae Sinensis (Dong Quai) and ipriflavone, wherein the combination of this second compositions suppresses the expression of RANK-L.
