Kevin W. Gellenbeck;Silvia R. da Costa;Mary A. Murray;Haeri Roh-Schmidt;Jatinder Rana;Yumei Lin;David J. Fast;Leon M. Wilkins;John F. Rebhun
发明人:
David W. Krempin,Mary A. Murray,Yumei Lin,Kevin W. Gellenbeck,Silvia R. da Costa,Leon M. Wilkins,Haeri Roh-Schmidt,Jatinder Rana,John F. Rebhun,David J. Fast
申请号：
US15235752
公开号：
US20160346344A1
申请日:
2016.08.12
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression； and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
