This Hair Ming Department Off Yu mono- Seed hepatitis C vaccines, it includes determine position Zhi Shao bis- Seed Kang Yuan Decision, each anti-original Decision determines position and determine position from one of the what difference anti-original Decision of Hot District, wherein the anti-original Decision of a Hot District, which determine portion Department, refers to that an antigen Decision determines position and contain to have victory peptide fragments of the Election from following group:KFPGGGQIVGGVYLLPRRGPRLGVRATRK,GYKVLVLNPSVAAT,AYAAQGYKVLVLNPSVAAT,DLMGYIP(A/L)VGAPL,GEVQVVSTATQSFLATCINGVCWTV,HMWNFISGIQYLAGLSTLPGNPA,VDYPYRLWHYPCT(V/I)N(F/Y)TIFK(V/I)RMYVGGVEHRL,AAWYELTPAETTVRLR,GQGWRLLAPITAYSQQTRGLLGCIV,IGLGKVLVDILAGYGAGVAGALVAFK,FTDNSSPPAVPQTFQV,LEDRDRSELSPLLLSTTEW,YLVAYQATVCARAQAPPPSWD,MSTNPKPQRKTKRNTNR,LINTNGSWHINRTALNCNDSL,TTILGIGTVLDQAET,FDS(S/V)VLCECYDAG(A/C)AWYE,ARLIVFPDLGVRVCEKMALY,AFCSAMYVGDLCGSV,GVLFGLAYFSMVGNW,VVCCSMSYTWTGALITPC,TRVPYFVRAQGLIRA and TTLLFNILGGWVAAQ.本發明係關於一種C型肝炎疫苗,其包含至少二種抗原決定部位,各抗原決定部位源自於不同之一熱區抗原決定部位,其中一熱區抗原決定部位係指一抗原決定部位含有選自下列族群之胜肽片段:KFPGGGQIVGGVYLLPRRGPRLGVRATRK、GYKVLVLNPSVAAT、AYAAQGYKVLVLNPSVAAT、DLMGYIP(A/L)VGAPL、GEVQVVSTATQSFLATCINGVCWTV、HMWNFISGIQYLAGLSTLPGNPA、VDYPYRLWHYPCT(V/I)N(F/Y)TIFK(V/I)RMYVGGVEHRL、AAWYELTPAETTVRLR、GQGWRLLAPITAYSQQTRGLLGCIV、IGLGKVLVDILAGYGAGVAGALVAFK、FTDNSSPPAVPQTFQV、LEDRDRSELSPLLLSTTEW、YLVAYQATVCARAQAPPPSWD、MSTNPKPQRKTKRNTNR、LINTNGSWHINRTALNCNDSL、TTILGIGTVLDQAET、FDS(S/V)VLCECYDAG(A/C)AWYE、ARLIVFPDLGVRVCEKMALY、AFCSAMYVGDLCGSV、GVLFGLAYFSMVGNW、VVCCSMSYTWTGALITPC、TRVPYFVRAQGLIRA及TTLLFNILGGWVAAQ。
