To provide a formulation that is sealed with a rubber stopper and charged into a medical container, in which temporal increases of N-formylpiperidine (NFP) are suppressed during its storage.SOLUTION: The present invention provides a production process of a lyophilized formulation that is sealed with a rubber stopper, is charged into a medical container, and contains teriparatide acetate of 67.9 μg as an active ingredient, the production process including the step of sealing a medical container with a lyophilized rubber stopper.SELECTED DRAWING: None【課題】ゴム栓で封栓され、医療用容器に充填されている製剤において、保存時におけるＮ－ホルミルピぺリジンの経時的増加を抑制する。【解決手段】ゴム栓で封栓され、医療用容器に充填されている、６７．９μｇのテリパラチド酢酸塩を有効成分として含有する凍結乾燥製剤の製造過程において、凍結乾燥されたゴム栓で医療用容器を封栓する工程を含む。【選択図】なし
