The present invention provides an electromagnetic wave therapy device and an immunotherapy method thereof, which sense an ambient temperature and a body temperature of a patient by a sensing unit, thereby generating a sensing signal. A control unit, based on indication information, sensing signals and finding a corresponding spectrum indication signal in the database. The baseband unit in the treatment device generates the therapeutic spectrum content corresponding to different waveforms, frequencies, amplitudes or timetable according to the therapeutic spectrum content, and then uses a radio frequency unit emitting a millimeter-wave at a frequency between 56 GHz and 65 GHz to become a millimeter-wave irradiation source, radiates a patient with a desired location to be treated, and allows the patient to perform a millimeter-wave immunotherapy program by radiating the millimeter-wave treatment device with a non-invasive way to achieve the bodys immune cells performance of the purpose and to control and change the human immune system.本發明提供一種電磁波治療裝置及其使用方法,其藉由一感測單元來感測使用環境及患者的身體溫度,並因此產生一感測訊號,一控制單元根據適應症資料、感測訊號而在數據資料庫中找出一相對應的頻譜指示訊號,治療裝置中的基頻單元根據頻譜指示訊號產生相對應不同波形、頻率、振幅或時域的治療頻譜內容,再藉由一射頻單元發射出頻率介於56GHz~65GHz之毫米波而成為一毫米波照射源,照射患者的欲治療體位,讓患者進行毫米波免疫治療程序,藉由此種非侵入式之毫米波治療裝置照射,以達到影響體內免疫細胞激素表現之目的,得以控制及改變人體免疫力。10 毫米波治療裝置 11 控制單元 113 第一控制指令 13 感測單元 135 感測訊號 15 記憶單元 150 數據參照表 151 適應症資料 153 若干細胞激素參數 157 氧化壓力指標參數 159 頻譜指示訊號 17 基頻單元 175 治療頻譜內容 19 射頻單元 195 毫米波照射源 20 患者 30 毫米波治療晶片