#$%^&*AU2020201700A120200326.pdf#####ABSTRACT An object of the present invention is to provide a method of preparing an enzyme-treated bovine colostrum, comprising a step of 5 bringing a bovine colostrum into contact with p-galactosidase, and a pharmaceutical composition comprising the enzyme-treated bovine colostrum. The enzyme-treated bovine colostrum is useful for treatment, prevention, amelioration and maintenance of remission of diseases such as a cancer and an infectious disease.