By a single administration, not only showing a remission effect of inflammatory bowel disease, indicating a remission maintaining effect for a long period of time, the anti-CD81 antibody, also the maintenance of remission medicament for inflammatory bowel disease, By showing prevention against inflammatory bowel disease refractory, treatment, the improvement effect, it is effective prevention of inflammatory bowel disease, improvement, as a medicament for the treatment.抗CD81抗体は、単回投与により、炎症性腸疾患の緩解導入効果を示すのみならず、長期間に亘って緩解維持効果を示すことで、炎症性腸疾患の緩解維持用医薬として、また、難治性の炎症性腸疾患に対しても予防、治療、改善効果を示すことで、炎症性腸疾患の予防、改善、治療用医薬として有効である。