At least, it included immunity stimulus, immunity control or immunity adjustment moteihu 1 and at the same time the natural phospho diester principal chain or the mononucleotide which possesses the principal chain which is decorated, it was selected from dinucleotide, origonukureochido or the polynucleotide, according to need the effective immunity adjustment nuclear acid component, inside the cell it becomes combining with the unique antigen including, being two functionality compositions, cholera toxin (CT), thermal unstable enterotokishin (LT) of sub unit B of CT (CTB) and Escherichia coli, it reacts with the antiserum for sub unit B of LT (LTB), and CT or LT, GM1 gangurioshido, ADP- riboshireto which is the receptor proteinIt connects, or, the target cell, and after connecting to the unique cell surface component, in the cell it becomes pertaining to the protein which is connected to the unique receptor on the mammalian cell surface which is selected from the group which consists of the protein or protein derivative which accumulates cyclic AMP to the antibody or the other protein which intanarizeshiyon can do, two functionality compositions are stated. This composition, the tumor and the infection symptom, transplantation refusal and immunity control state, is useful in the autoimmune disease, and remedy of the allergy in addition furthermore with the unique antigen, immunity prevention, immunity medical therapy or inducement, and vaccination or immunity medical therapy of tolerance with purpose afterwards is useful even in dosage with x bibo of the antigen offer cell in order the transportation liquid to do.少なくとも1個の免疫刺激、免疫抑制または免疫調節モティーフを含み且つ天然のホスホジエステル主鎖または修飾した主鎖を有するモノヌクレオチド、ジヌクレオチド、オリゴヌクレオチドまたはポリヌクレオチドから選択された、細胞内で有効な免疫調節核酸成分を、必要に応じて特異抗原と組み合わせて含んでなる、二官能性組成物であって、コレラ毒素(CT)、CTのサブユニットB(CTB)、Escherichia coliの熱不安定性エンテロトキシン(LT)、LTのサブユニットB(LTB)、およびCTまたはLTに対する抗血清と反応し、GM1ガングリオシド、受容体タンパク質であるADP-リボシレートに結合するか、または、ターゲット細胞、および特異的細胞表面成分に結合した後に細胞中にインターナリゼーションすることができる抗体または他のタンパ
