Provided is a transdermal absorption patch containing a serotonin receptor antagonist which shows a short transdermal absorption delay time (Lag time), can reach the maximum flux of the drug in a short time, and exhibits a rapid drug elimination rate from the circulating blood. More specifically, provided is a patch containing a serotonin receptor antagonist such as granisetron as an active ingredient in an adhesive layer which contains a non-functionalized acrylic adhesive, a water-soluble organic amine and a fatty acid ester.本發明係提供一種具有短經皮吸收延遲時間(lag time)，以短時間即可到達藥物之最大皮膚通透速度，且自循環血液中藥物之消失速度快，經皮吸收型之含有血清素受體拮抗劑之貼劑。亦即，本發明係提供於摻混非官能性之丙烯酸系黏著劑、水溶性有機胺以及脂肪酸酯而成之黏著劑層中，摻混有作為藥效成分之康您適強(granisetron)等血清素受體拮抗劑之貼劑。
