A kind of isolation subunit, including a kind of aversive agent and a kind of blocking agent, wherein the blocking agent is essentially prevented the aversive agent release reaches big what 24 hours one periods from the isolation subunit in gastrointestinal tract； A kind of composition includes a kind of isolation subunit and a kind of therapeutic agent of releasable form, wherein optionally, the mechanical equivalent of light fragility of the isolation subunit is identical as the mechanical equivalent of light fragility of the therapeutic agent of the releasable form； A kind of capsule or tablet, including a kind of isolation subunit and a kind of therapeutic agent； A kind of and method for preventing abuse therapeutic agent.一種隔離亞單元，包括一種厭惡劑和一種阻斷劑，其中該阻斷劑基本上阻止該厭惡劑在胃腸道內從該隔離亞單元中釋放達大於24小時的一段時期；一種組合物包括一種隔離亞單元和一種可釋放形式的治療劑，其中，任選地，該隔離亞單元的機械脆性與該可釋放形式的治療劑的機械脆性相同；一種膠囊劑或片劑，包括一種隔離亞單元和一種治療劑；及一種防止濫用治療劑的方法。
