Marianne Bruggemann,Roland Buelow,Michael J. Osborn,Biao Ma
申请号:
US15332583
公开号:
US10385132B2
申请日:
2016.10.24
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The invention relates to polynucleotides, particularly chimeric polynucleotides useful for optimal production of functional immunoglobulins with human idiotypes in rodents. The invention further relates to rodents comprising such polynucleotides.