The present invention provides a bone cement composition. The bone cement composition includes a bone matrix and a bone cement matrix formed by an acrylic polymer and an acrylic monomer, wherein the ratio of the bone matrix and the bone cement matrix is in a range from about 1:2 (g/g) to about 1:1000 (g/g). The present invention further provides a bone cement composition kit. The bone cement composition kit includes a bone matrix component, a powder component and a liquid component stored in separate containers, respectively, wherein the bone matrix component includes a bone matrix, the powder component includes an acrylic polymer, and the liquid component includes an acrylic monomer. The powder component and the liquid component are mixed to form a bone cement matrix component. A ratio of the bone matrix component and the bone cement matrix component is in a range from about 1:2 (mL/mL) to about 1:50 (mL/mL).本發明提供一種骨水泥組合物,其包含骨基質以及丙烯酸酯系聚合物與丙烯酸酯系單體形成之骨水泥基材,其中該骨基質與該骨水泥基材之比例為約1:2 (克/克)至約1:1000 (克/克)範圍。本發明另提供一種骨水泥組合物套組,其包含分別儲存於單獨容器中之骨基質成份、粉體成份及液體成份,其中該骨基質成份包含骨基質,該粉體成份包含丙烯酸酯系聚合物,該液體成份包含丙烯酸酯系單體,該粉體成份與該液體成份混合形成骨水泥基材成份,該骨基質成份與該骨水泥基材成份之比例為約1:2 (毫升/毫升)至約1:50 (毫升/毫升)範圍。(無)