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Benzoxazolinone compounds with selective activity in voltage-gated sodium channels
专利权人:
发明人:
Joseph E. Pero,Hannah D. G. F. Lehman,Michael J. Kelly, III,Lianyun Zhao,Michael A. Rossi,Dansu Li,Kevin F. Gilbert,Scott Wolkenberg,James Mulhearn,Mark E. Layton,Pablo de Leon
申请号:
US14437315
公开号:
US09624208B2
申请日:
2013.10.23
申请国别(地区):
US
年份:
2017
代理人:
摘要:
Disclosed are compounds of Formula A: Formula A, or a salt thereof, wherein “Het”, Ra, and Rb are defined herein, which have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A or their salts, and methods of treating neuropathic pain disorders using the same.
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