Isadora Cristina Siqueira;Lee W. Riley;David A. Haake;Julio Henrique Rosa Croda;Tracy Ann Young;Albert I. Ko;James Matsunaga;Mitermayer Galvão Reis;Michele Barocchi
发明人:
Albert I. Ko,Mitermayer Galvão Reis,Julio Henrique Rosa Croda,Isadora Cristina Siqueira,David A. Haake,James Matsunaga,Lee W. Riley,Michele Barocchi,Tracy Ann Young
申请号：
US13359354
公开号：
US20120121639A1
申请日:
2012.01.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.
