The United States of America represented by the Department of Veterans Affairs;The Regents of the University of California;Cornell Research Foundation, Inc.;Fundação Oswaldo Cruz—FIOCRUZ
发明人:
Albert I. Ko,Mitermayer Galvão Reis,Julio Henrique Rosa Croda,Isadora Cristina Siqueira,David A. Haake,James Matsunaga,Lee W. Riley,Michele Barocchi,Tracy Ann Young
申请号：
US15334128
公开号：
US09932391B2
申请日:
2016.10.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.
