Knappe, Thomas,Laufer, Burkhardt,Rau, Harald,Voigt, Tobias,Weisbrod, Samuel,Reimann, Romy,Sprogøe, Kennett,Bisek, Nicola,Stark, Sebastian
申请号：
NZ70685313
公开号：
NZ706853A
申请日:
2013.10.08
申请国别(地区):
NZ
年份:
2018
代理人:
摘要：
The present invention relates to a pharmaceutical composition comprising one or more pharmaceutically acceptable excipient(s) and a carrier-linked VEGF neutralizing prodrug, the carrier-linked prodrug comprising a covalently bound VEGF neutralizing biologically active moiety, for use in a method for the treatment of one or more ocular conditions., wherein the carrier-linked prodrug comprises a covalently bound VEGF neutralizing biologically active moiety, a reversible prodrug linker moiety and a carrier group which is a hydrogel, which VEGF neutralizing biologically active moiety is reversibly connected to a carrier through a reversible prodrug linker moiety, wherein there is optionally a spacer moiety between the carrier moiety and the reversible prodrug linker and wherein the reversible prodrug linker is of formula (F) below, for use in a method for the treatment of one or more ocular conditions.
