The disclosure provides among other things compositions that bind to and inhibit the biological activity of soluble biomolecules as well as pharmaceutical compositions thereof. The compositions may comprise a plurality of particles that specifically bind a target such as a soluble biomolecule or a biomolecule on the surface of a pathogen to inhibit the target (or pathogen) from interacting with other molecules or cells. Also provided herein are a number of applications (e.g. therapeutic applications) in which the compositions are useful.
