Helen M. Blau,Nidhi Bhutani,Jennifer Brady,Mara Damian
申请号：
US13511989
公开号：
US20130011380A1
申请日:
2010.12.17
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Methods, compositions and kits for modulating demethylation in a mammalian cell are provided. Also provided are methods, compositions and kits for screening candidate agents for activity in modulating genomic DNA demethylation in mammalian cells. These methods, compositions and kits find use in producing induced pluripotent stem cells (iPS) and somatic cells in vitro and for treating human disorders including cancer and disorders arising from defects in genomic imprinting.
