The present disclosure is directed to a device for medical examination in a subject. The device is configured for easy self-examination of a variety of physiological parameters indicative of disease or physiological irregularities. Examples of such physiological parameters include body temperature indicative of fever, ear pathologies indicative of ear infection, heartbeat, blood oxygen level. While the device of this disclosure may be a stand-alone device, it may be configured, according to embodiments of this disclosure, for association and operation with a mobile communication device, in particular a smartphone.