REGENERON PHARMACEUTICALS INC.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人:
LAI, Ka-man Venus KV,GONG, Guochun G,RINN, John J,FRENDEWEY, David D,VALENZUELA, David M. DM,‧賴,‧龔,‧裡恩,‧弗倫德維,‧瓦倫澤拉
申请号：
HK16109080.4
公开号：
HK1220990A
申请日:
2016.07.29
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
Genetically modified non-human animals are provided that exhibit a functional lack of one or more IncRNAs. Methods and compositions for disrupting, deleting, and/or replacing IncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more IncRNAs.
