Bruno Robert,Benedicte Fauvel,Gwenael Cheve,Aziz Yasri,Christel Larbouret,Wilhem Leconet,Thierry Chardes,Christian Larroque,Andre Pelegrin
申请号：
US14127415
公开号：
US09249228B2
申请日:
2012.06.22
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to anti-Axl antibodies and uses thereof in diagnostic and therapeutic methods. More particularly, the present invention relates to a monoclonal antibody having specificity for Axl comprising an heavy chain variable region comprising SEQ ID NO:2 in the H-CDR1 region, SEQ ID NO:3 in the H-CDR2 region and SEQ ID NO:4 in the H-CDR3 region； and a light chain variable region comprising SEQ ID NO: 6 in the L-CDR1 region, SEQ ID NO:7 in the L-CDR2 region and SEQ ID NO:8 in the L-CDR3 region. Said monoclonal antibody binds to the extracellular domain of Axl via, SEQ ID NO:9, SEQ ID NO: 10 and SEQ ID NO: 11.
