PROBLEM TO BE SOLVED: To provide a novel anti-inflammatory polypeptide derived from phycobiliprotein included in red algae which are marine resources, and to provide an anti-inflammatory composition containing this.SOLUTION: The invention provides a polypeptide consisting of a specific amino acid sequence, or an amino acid sequence in which 1-3 amino acid residues of the specific amino acid sequence are substituted or deleted, or an amino acid sequence in which 1-3 amino acid residues are added to the specific amino acid sequence, and having anti-inflammatory activity and an anti-inflammatory composition containing the polypeptide. The polypeptide and the anti-inflammatory composition are available as a polypeptide or an anti-inflammatory composition excellent in safety, derived from algae which are natural marine resources.SELECTED DRAWING: Figure 1COPYRIGHT: (C)2016,JPO&INPIT【課題】海洋資源である紅藻類に含まれるフィコビリタンパク質に由来する、新たな抗炎症性ポリペプチドとこれを含む抗炎症性組成物を提供する。【解決手段】特定のアミノ酸配列からなるポリペプチド、又は前記特定のアミノ酸配列の1~3つのアミノ酸残基が置換され若しくは欠失したアミノ酸配列若しくは前記特定のアミノ酸配列に1~3つのアミノ酸残基が付加されたアミノ酸配列からなり、かつ抗炎症活性を有するポリペプチド、さらに、前記ポリペプチドを含有する抗炎症性組成物。該ポリペプチド及び該抗炎症性組成物は、天然の海洋資源である藻類に由来する安全性に優れたポリペプチド又は抗炎症性組成物として利用可能である。【選択図】図1