YING, Wenbin,MINOMI, Kenjirou,HARBORTH, Jens,TAKAHASHI, Hirokazu,TERADA, Erika,ZHANG, Jun,AHMADIAN, Mohammad
申请号：
HK18105480.6
公开号：
HK1245674A
申请日:
2018.04.27
申请国别(地区):
HK
年份:
2018
代理人:
摘要：
PROBLEM TO BE SOLVED: To provide compounds, compositions and methods for modulating the expression of human GST-π using RNA interference.SOLUTION: Provided are a range of siRNAs, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2'-deoxy nucleotides located in the seed region, as well as other nucleotide modifications. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor.SELECTED DRAWING: Figure 1
