Klaus Pfizenmaier;Peter Scheurich;Roland Kontermann;Sabine Münkel
发明人:
Klaus Pfizenmaier,Peter Scheurich,Roland Kontermann,Sabine Münkel
申请号：
US12531000
公开号：
US08404238B2
申请日:
2008.03.13
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to a ligand, which specifically binds to human tumor necrosis factor type 1 receptor (huTNFR1). The ligand includes one or more amino acid sequences of human origin capable of reducing the immunogenic response of the ligand in humans and one or more amino acid sequences capable of selectively binding to huTNFR1. The present invention also relates to a nucleic acid sequence encoding the ligand and to a pharmaceutical composition for the treatment of disorders related to huTNFR1.
